Creatinine Levels GFR Calculator

CKD-EPI Equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times (1.159 \text{ if black}) \]

Serum Creatinine (SCr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What Is Creatinine Levels GFR Calculator?

The Creatinine Levels GFR Calculator uses the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation to estimate glomerular filtration rate (GFR) from serum creatinine levels, age, sex, and race. This provides a precise assessment of kidney function and is particularly valuable for early detection of kidney disease.

2. How Does The Calculator Work?

The calculator employs the CKD-EPI equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times (1.159 \text{ if black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( age \) — Age in years
1.018 — Female multiplier
1.159 — Black race multiplier

Explanation: This sophisticated equation accounts for the non-linear relationship between serum creatinine levels and glomerular filtration rate, with optimized coefficients for different demographic groups to ensure maximum accuracy.

3. Importance Of eGFR Calculation

Details: Accurate estimation of glomerular filtration rate is essential for diagnosing chronic kidney disease, determining the precise stage of kidney impairment, guiding appropriate medication dosing based on renal function, and monitoring disease progression over time.

4. Using The Calculator

Tips: Enter serum creatinine value in mg/dL, age in complete years, select appropriate gender and race. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: Why Choose CKD-EPI Over Other Equations?
A: The CKD-EPI equation demonstrates superior accuracy at higher GFR levels (>60 mL/min/1.73m²) and reduces the likelihood of misclassifying individuals with mildly impaired kidney function.

Q2: What Constitutes Normal eGFR Values?
A: Normal glomerular filtration rate is generally ≥90 mL/min/1.73m², though physiological decline occurs with advancing age. Values persistently below 60 mL/min/1.73m² for three months or longer indicate chronic kidney disease.

Q3: When Should Serum Creatinine Be Measured?
A: Morning fasting samples provide optimal results, though random samples are clinically acceptable. Avoid testing shortly after consuming protein-rich meals or engaging in strenuous physical activity.

Q4: What Are The Limitations Of This Equation?
A: Reduced accuracy may occur in extreme age groups, amputees, pregnant women, individuals with significant muscle mass variations, and patients with rapidly fluctuating kidney function.

Q5: Is This Suitable For Drug Dosing Decisions?
A: While useful for screening and monitoring, precise drug dosing in critical situations may require measured GFR techniques such as iohexol clearance, particularly in special populations.