Creatinine Clearance Ml/Min Calculator

Cockcroft-Gault Equation:

\[ CrCl = \frac{(140 - Age) \times Weight}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

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1. What is the Cockcroft-Gault Equation?

The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and for assessing kidney function.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault equation:

\[ CrCl = \frac{(140 - Age) \times Weight}{72 \times SCr} \]

Where:

\( Age \) — Age in years
\( Weight \) — Body weight in kilograms
\( SCr \) — Serum creatinine in mg/dL
Multiply result by 0.85 for females

Explanation: The equation estimates the rate at which creatinine is cleared from the blood by the kidneys, providing an approximation of glomerular filtration rate.

3. Importance of Creatinine Clearance Calculation

Details: Creatinine clearance is essential for drug dosing adjustments, assessing renal function, and monitoring kidney disease progression. Many medications require dose modification based on CrCl values.

4. Using the Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. Use actual body weight unless patient is obese, in which case ideal body weight may be more appropriate.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between CrCl and eGFR?
A: CrCl estimates creatinine clearance while eGFR estimates glomerular filtration rate. CrCl is often used for drug dosing, while eGFR is used for CKD staging.

Q2: What are normal CrCl values?
A: Normal CrCl is approximately 95-125 mL/min for young adults, declining with age. Values below 60 mL/min indicate renal impairment.

Q3: When should ideal body weight be used?
A: For obese patients (BMI > 30), ideal body weight is often recommended instead of actual body weight for more accurate calculation.

Q4: Are there limitations to this equation?
A: Less accurate in elderly, malnourished, obese patients, and those with unstable renal function or extreme muscle mass.

Q5: Can this be used for all drug dosing?
A: While widely used, some drugs may require more precise GFR measurements or specific dosing protocols. Always consult prescribing information.