Creatinine Clearance Calculator For CKD

Cockcroft-Gault Equation:

\[ CrCl = \frac{(140 - Age) \times Weight \times 0.85 \text{ (if female)}}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

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1. What is Creatinine Clearance?

Creatinine clearance (CrCl) is a measure of kidney function that estimates the glomerular filtration rate (GFR). The Cockcroft-Gault equation is widely used to calculate CrCl for chronic kidney disease (CKD) staging and drug dosing adjustments.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault equation:

\[ CrCl = \frac{(140 - Age) \times Weight \times 0.85 \text{ (if female)}}{72 \times SCr} \]

Where:

\( Age \) — Age in years
\( Weight \) — Body weight in kilograms
\( SCr \) — Serum creatinine in mg/dL
\( 0.85 \) — Female adjustment factor

Explanation: This equation estimates creatinine clearance based on age, weight, serum creatinine level, and gender, providing a practical assessment of kidney function.

3. Importance of CrCl Calculation

Details: Creatinine clearance is essential for diagnosing and staging chronic kidney disease, adjusting medication dosages for renally excreted drugs, and monitoring kidney function over time.

4. Using the Calculator

Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age 1-120 years, weight > 0 kg, creatinine > 0 mg/dL).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between CrCl and eGFR?
A: CrCl estimates creatinine clearance using the Cockcroft-Gault equation, while eGFR estimates glomerular filtration rate using equations like CKD-EPI or MDRD.

Q2: What are normal CrCl values?
A: Normal CrCl is approximately 90-120 mL/min for young adults, decreasing with age. Values below 60 mL/min may indicate kidney impairment.

Q3: When is CrCl preferred over eGFR?
A: CrCl is often preferred for drug dosing adjustments, especially for medications with narrow therapeutic windows that are renally excreted.

Q4: Are there limitations to the Cockcroft-Gault equation?
A: It may overestimate CrCl in elderly, obese, or edematous patients and may be less accurate in those with extreme body weights or muscle mass.

Q5: Should ideal body weight be used?
A: For obese patients, some guidelines recommend using ideal body weight rather than actual body weight in the calculation.