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Cockcroft-Gault Equation:
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The Adult Estimated Creatinine Clearance Calculator uses the Cockcroft-Gault equation to estimate creatinine clearance from serum creatinine, age, and weight. It provides an assessment of renal function and is commonly used for drug dosing adjustments.
The calculator uses the Cockcroft-Gault equation:
Where:
Explanation: The equation estimates creatinine clearance based on the inverse relationship between serum creatinine and renal function, adjusted for age-related decline in kidney function and body size.
Details: Accurate creatinine clearance estimation is crucial for medication dosing, particularly for drugs that are renally eliminated. It helps prevent toxicity from overdosing in patients with impaired renal function.
Tips: Enter age in years (must be 18 or older), weight in kilograms, and serum creatinine in mg/dL. All values must be valid (age ≥18, weight >0, SCr >0).
Q1: What is the difference between eCrCl and eGFR?
A: eCrCl estimates creatinine clearance using the Cockcroft-Gault equation, while eGFR estimates glomerular filtration rate using equations like CKD-EPI or MDRD. eCrCl is often preferred for drug dosing.
Q2: What are normal creatinine clearance values?
A: Normal values are approximately 90-120 mL/min for young adults, declining with age. Values below 60 mL/min indicate impaired renal function.
Q3: When should this equation not be used?
A: Not recommended for children, elderly with significant muscle wasting, amputees, pregnant women, or patients with rapidly changing renal function.
Q4: How does weight affect the calculation?
A: The equation uses actual body weight. For obese patients, some clinicians use ideal body weight or adjusted body weight.
Q5: Is this equation adjusted for gender?
A: The basic Cockcroft-Gault equation shown here is not gender-adjusted. Some variations multiply the result by 0.85 for females.