Adult Creatinine Clearance Calculator

Cockcroft-Gault Formula:

\[ CrCl = \frac{(140 - Age) \times Weight \times (0.85 \text{ if female})}{72 \times SCr} \]

Age:

years

Weight:

Serum Creatinine (SCr):

mg/dL

Gender:

Creatinine Clearance (CrCl):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What is the Cockcroft-Gault Formula?

The Cockcroft-Gault formula is a widely used method for estimating creatinine clearance (CrCl) in adults. It provides an approximation of glomerular filtration rate based on serum creatinine, age, weight, and gender.

2. How Does the Calculator Work?

The calculator uses the Cockcroft-Gault formula:

\[ CrCl = \frac{(140 - Age) \times Weight \times (0.85 \text{ if female})}{72 \times SCr} \]

Where:

\( Age \) — Age in years (adults only)
\( Weight \) — Body weight in kilograms
\( SCr \) — Serum creatinine in mg/dL
0.85 — Female gender adjustment factor

Explanation: The formula estimates creatinine clearance by accounting for age-related decline in kidney function, body size, and gender differences in muscle mass.

3. Importance of Creatinine Clearance Calculation

Details: Creatinine clearance is crucial for assessing kidney function, determining appropriate drug dosages (especially for renally excreted medications), and monitoring patients with kidney disease.

4. Using the Calculator

Tips: Enter age (must be 18+ years), weight in kg, serum creatinine in mg/dL, and select gender. All values must be valid positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between CrCl and eGFR?
A: CrCl estimates creatinine clearance while eGFR estimates glomerular filtration rate. CrCl is often used for drug dosing, while eGFR is used for CKD staging.

Q2: Why is there a gender adjustment?
A: Women typically have less muscle mass than men, resulting in lower creatinine production. The 0.85 factor adjusts for this difference.

Q3: What are normal CrCl values?
A: Normal CrCl is approximately 90-120 mL/min for young adults, declining with age. Values below 60 mL/min may indicate impaired kidney function.

Q4: Are there limitations to this formula?
A: The formula may overestimate CrCl in elderly, obese, or edematous patients, and may be less accurate in those with extreme body weights or muscle mass.

Q5: Can this be used for pediatric patients?
A: No, the Cockcroft-Gault formula is validated for adults only. Different equations should be used for pediatric patients.